ABSTRACT
Background: Recurrent pregnancy loss [RPL] is caused by different factors, including genetics and thrombophilia. Beside Factor V Leiden, another nucleotide change in a factor V [FV] gene [A4070G; His1299Arg] has been identified linking to hereditary thrombophilia. Also, two proposed MTHFR polymorphisms, C677T and A1298C [Glu429A] are linked with RPL
Objective: In this study, the effect of two factors, A4070G in FV and A1298C in MTHFR are evaluated in RPL patients from Mazandaran province, Iran
Materials and Methods: Sample population of 100 women with RPL and 100 controls with Mazandarani ethnics from northern Iran were consist. The factor V [A4070G] and MTHFR [A1298C] polymorphisms were genotyped by PCR-RFLP
Results: Molecular study showed 5 women from patients and 9 women from control group were heterozygous AG for A4070G. Frequency of "A" allele in patient and control groups was 97.5% [0.975] and 95.5% [0.955] respectively, and "G" allele frequency was 2.5% [0.025] and 4.5% [0.045] respectively. No significant association [p
Conclusion: Our finding showed that A4070G and A1298C polymorphisms cannot be considered as a cause of PRL in women from Mazandaran province, northern Iran